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AGGRENOX
ASPIRIN/DIPYRIDAMOLE ER - ORAL

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

ASPIRIN/DIPYRIDAMOLE ER - ORAL

(ASP-er-in w/dye-pie-RID-uh-mole)

COMMON BRAND NAME(S): Aggrenox

WARNING: Children and teenagers should not use aspirin, aspirin- containing or aspirin-related medications for flu symptoms or chickenpox without first consulting a doctor. A rare but serious illness known as Reye's syndrome may occur.

Uses

This medication is used to prevent stroke.

How To Use

Take this medication by mouth, generally one capsule twice a day, in the morning and in the evening, or as directed by your doctor. Swallow the capsule whole. Do not crush or chew the capsule. Take this medication with a full glass (8 oz or 240 ml) of water unless your doctor directs you otherwise. Do not lie down for at least 30 minutes after taking this drug. This capsule is not interchangeable with doses of aspirin and dipyridamole given as separate pills. Consult your pharmacist for more information.

Side Effects

Nausea, diarrhea, stomach upset or drowsiness may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these very unlikely, but serious side effects occur: hearing changes, ringing in the ears, severe headache, mental/mood changes, unusual weakness, slurred speech, vision problems, black/bloody stools, easy bleeding or bruising, yellowing eyes or skin, dark urine, chest pain, change in the amount of urine, fast/slow or irregular pulse. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Tell your doctor your medical history, including: any allergies - especially to dipyridamole or aspirin/NSAIDs (e.g., ibuprofen, celecoxib), liver problems, kidney problems, asthma, growths in the nose (nasal polyps), chronic runny nose (rhinitis), blood or bleeding disorders (e.g., vitamin K deficiency), low blood pressure (hypotension), heart problems (e.g., angina, heart failure or heart attack), stroke or brain bleed, alcohol dependence, ulcers. This drug may make you drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcohol intake because it can intensify the drowsiness effect of this medication. This medicine may cause stomach bleeding. Daily use of alcohol, especially when combined with this medicine, may increase your risk for stomach bleeding. The amount of aspirin in this medication may not be effective for the prevention of heart attack. If you require aspirin to prevent heart attack, consult your doctor or pharmacist for more information. This drug contains aspirin. Children and teenagers should not take aspirin if they have chickenpox, influenza or any undiagnosed illness without first consulting a doctor about Reye's syndrome, a rare but serious illness. Caution is advised when using this drug in the elderly since they may be more sensitive to the effects of this drug. This medication should be used only when clearly needed during the first six months of pregnancy. This medication is not recommended for use during the last three months of pregnancy. Discuss the risks and benefits with your doctor. The aspirin and dipyridamole in this medication may pass into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription medication you may use, especially: NSAIDs (e.g., ibuprofen, ketoprofen, naproxen), ACE inhibitors (e.g., enalapril, lisinopril), angiotensin blockers (e.g., losartan), "blood thinners" (e.g., warfarin, heparins), beta-blockers (e.g., atenolol, metoprolol), "water pills" (e.g. furosemide, hydrochlorothiazide), diabetes medications (e.g., glipizide, glyburide), gout medications (e.g., probenecid, sulfinpyrazone), cholinesterase inhibitors (e.g., edrophonium, physostigmine), high blood pressure medicines, aspirin, adenosine, acetazolamide, phenytoin, valproic acid, methotrexate. Check the label on all your pain relievers/fever reducers because they may contain aspirin or NSAIDs (e.g., ibuprofen, ketoprofen, naproxen). Ask your pharmacist about the safe use of those products. Also report any drugs that cause drowsiness, such as: medicine for sleep, sedatives, tranquilizers, anti-anxiety drugs, narcotic pain relievers (e.g., codeine), psychiatric medicines, anti- seizure drugs, muscle relaxants, antihistamines that cause drowsiness (e.g., diphenhydramine). Check the labels on all your medicines (e.g., cough-and- cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products. The aspirin in this product can affect the results of certain laboratory tests. Make sure laboratory personnel and your doctors know you use this drug. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include ringing in the ears, flushing, sweating, restlessness, weakness, dizziness and fast heartbeat.

Notes

Do not share this medication with others.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from light and moisture.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).